PARTIAL AGONIST BEHAVIOUR OF ADENOSINE 5′O-(2-THIODIPHOSPHATE) ON HUMAN PLATELETS
نویسندگان
چکیده
منابع مشابه
Effects of photolysable 2-azido analogues of adenosine, AMP and ADP on human platelets.
The aggregating effect of ADP on human platelets and the inhibiting effect of adenosine are apparently mediated by different receptors on the cells’ outer membranes. Photolysable azido-analogues of adenosine, AMP and ADP have been prepared so tha t the receptors for them can be labelled. 2-Azidoadenosine inhibited platelet aggregation by ADP more than adenosine itself and increased platelet cAM...
متن کاملContact- and agonist-regulated microvesiculation of human platelets.
After exposure to an agonist, platelets are activated and become aggregated. They also shed membrane microparticles that participate in the pathogenesis of thrombosis, hyper-coagulation and inflammation. However, microvesiculation can potentially disrupt the integrity of platelet aggregation by shedding the membrane receptors and phosphatidylserine critical for forming and stabilising a platele...
متن کاملResolvin E1 regulates adenosine diphosphate activation of human platelets.
OBJECTIVE To investigate the ability of resolvin E1 (RvE1) to regulate adenosine diphosphate (ADP) activation of platelets via specific receptors because RvE1 reduces platelet aggregation with certain agonists, including ADP. METHODS AND RESULTS RvE1 is an eicosapentaenoic acid-derived specialized proresolving mediator generated during the resolution of acute inflammation. RvE1 exhibits poten...
متن کاملBinding of adenosine diphosphate by isolated membranes from human platelets.
Binding of adenosine diphosphate by isolated membranes from human platelets has been demonstrated. The process was reversible, temperature-dependent, supported by calcium or magnesium ions, and influenced by the integrity of membrane protein sulfhydryl groups. Prior exposure of the isolated membranes to trypsin, chymotrypsin, or pronase resulted in significant inhibition of [i4C]ADP uptake. Ext...
متن کاملAgonist action of adenosine triphosphates at the human P2Y1 receptor.
The agonist selectivity for adenosine di- and triphosphates was determined for the human P2Y1 receptor stably expressed in human 1321N1 astrocytoma cells and was studied under conditions in which nucleotide metabolism was both minimized and assessed. Cells were grown at low density on glass coverslips, encased in a flow-through chamber, and continuously superfused with medium, and Ca2+ response...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1981
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1981.tb10436.x